To make room for Lewis on the 53-man roster, the team placed rookie receiver Allen Robinson on injured reserve with a broken right foot.
The Jaguars also waived rookie tight end Mike Flacco from the practice squad and waived rookie receiver Nathan Slaughter from injured reserve.
Robinson injured his foot against Dallas in London on Nov. 9.
Lewis sustained a high-ankle sprain at Washington on Sept. 14 and was placed on injured reserve two days later with a designation to return. He has been running and working for weeks and is expected to provide an immediate impact Sunday at Indianapolis.