It didn't matter.
Napoli hit two homers and drove in three runs, carrying the Boston Red Sox to an 8-3 win over the Angels on Saturday night.
Coming into the game, Napoli hit just .194 with one homer and six RBIs against Wilson.
"My numbers against Nap are, I'd say, good overall," Wilson said. "So it's an anomaly tonight to give up two home runs. He's got one homer off me before tonight, it was because I threw him like six back-door cutters in a row in Anaheim in 2011, so that's the last time he hit a homer off me."
Napoli improved his numbers to .327 with 17 homers and 32 RBIs in 46 games against the Angels.
"I think the bigger story for C.J. wasn't just against Mike," Angels manager Mike Scioscia said. "As the game went on, he was just trying to get back into too many counts. He put them in a lot of hitting counts. Times he got back in and got it done, but it came back and snake bit him in the end."
Wilson (2-3) threw a season-high 119 pitches over six innings, giving up four runs on seven hits, fanning six and walking three.
Xander Bogaerts had a two-run single and Mookie Betts, two RBI singles for Boston, which had a shuffled batting order with Dustin Pedroia leading off and David Ortiz batting cleanup, moving from his customary third spot.
Steven Wright (2-1) allowed two runs and four hits, striking two and walking just one. The knuckleballer retired 18 of 19 batters after Calhoun's double before being pulled following a one-out walk in the seventh.
Napoli's second homer — a two-run shot that completely left Fenway Park, clearing the Green Monster seats — broke a 2-2 tie in the sixth. It was his third in two days and his fourth in five games.
It was the most runs scored by Boston since an 11-8 loss at home against Toronto on April 28.
Bogaerts' single gave Boston a 6-2 cushion in the seventh.
Napoli's first homer went into the second row of Monster seats, hitting a handmade sign on the back of the row with a bull's-eye and read "It's my Birthday. Hit it to me."
THAT STREAK'S OVER
The Angels had won five straight against the Red Sox. They also had won 11 of their last 13 in Fenway.
NEED IT FOR WINNING TRIP
Los Angeles closes a 10-game AL East swing on Sunday. They need a victory for a winning trip after going 2-1 in Baltimore and 2-2 in Toronto.
Angels: Reliever Mike Morin walked off the mound after throwing a pitch in the seventh. He has a left oblique strain. "Mike felt something in his oblique. He's going to go on the DL," Scioscia said. "We'll have a corresponding move tomorrow."
Red Sox: 3B Pablo Sandoval, who hasn't started a game since being hit on the side of the left knee on Tuesday, wasn't in the lineup again Saturday. Manager John Farrell said he was available, but didn't start with a left-hander going for Los Angeles. The switch-hitting Sandoval is 2 for 41 from the right side. ... RF Shane Victorino left the game with left calf tightness. He was scratched Thursday and didn't play Friday due to the sore calf.
Angels: LHP Hector Santiago (3-2, 2.25 ERA) is slated to start the series finale. He's allowed one or no runs in six of his seven starts.
Red Sox: LHP Wade Miley (3-4, 5.10 ERA) is scheduled to start for Boston in the finale of its six-game homestand. He'll be facing the Angels for the first time in his career and comes in off consecutive strong starts, earning two wins while allowing two runs over 13 2-3 innings.