STILLWATER, Oklahoma — Texas Tech might have lost much more than a game on Thursday night.
Davis Webb passed for 374 yards and four touchdowns for the Red Raiders before leaving in the fourth quarter of a 45-35 loss to No. 24 Oklahoma State with a left shoulder injury. His availability for Tech's Oct. 4 game at Kansas State is unclear.
"I'm not sure," Texas Tech coach Kliff Kingsbury said after the game. "I just know that they didn't feel like he could come back in tonight."
The injury to Webb's non-throwing shoulder forced him from the game with his team trailing 38-28. He went to the locker room, but later returned to the sideline.
Freshman Pat Mahomes stepped in for Webb and completed two of five passes for 20 yards, a touchdown and an interception.
"He was up and down, I thought," Kingsbury said. "He's a competitor, so he came in and fought, but your first playing time is a little rough."
Brad Marquez had eight catches for 106 yards for the Red Raiders (2-2, 0-1 Big 12). Jakeem Grant had a career-high 12 receptions for 100 yards and a touchdown, and Reginald Davis caught two touchdown passes.
Oklahoma State has won six straight against the Red Raiders and has averaged 55.5 points in the past four wins. The Red Raiders haven't won in Stillwater since 2001.
Mike Smith took over as Texas Tech's interim defensive coordinator after Matt Wallerstedt resigned from their shared position as co-coordinators. The Red Raiders surrendered 528 yards.
It was a typical shootout in the series. The teams combined for 1,034 yards. They also combined for 287 yards in penalties.
Texas Tech marched down the field on its opening drive, and Webb found Davis down the middle for a 21-yard touchdown. Webb was 7 of 9 on the drive.
Oklahoma State tied it late in the first quarter when Washington made an in-air adjustment in the end zone to snag a 33-yard pass from Garman.
Webb completed 18 of 26 passes for 175 yards in the first quarter.
Ramon Richards, playing because Ashton Lampkin was injured in the first quarter, intercepted Webb's first pass of the second quarter. Texas Tech's defense held, and then Webb found Marquez for an 18-yard touchdown pass that gave the Red Raiders a 14-7 lead.
Jeremy Seaton's leaping 28-yard catch between three defenders set up a 1-yard touchdown run by Roland that tied it with 7 minutes left in the second quarter.
Kevin Peterson intercepted Webb's pass, and then Garman took advantage on the next play with a 39-yard touchdown pass to Washington that gave Oklahoma State a 21-14 lead.
Texas Tech gained 340 yards in the first half, but only scored 14 points.
Garman struck again early in the third quarter with a 47-yard touchdown pass to tight end Blake Jarwin.
Tech hung tough. Justin Stockton caught a 17-yard scoring pass from Webb to make it 28-21, but Garman came right back and hit Tyreek Hill deep for a 50-yard touchdown pass that put the Cowboys up by 14 again. The ball appeared to be overthrown, but Hill, a track sprinter, shifted into another gear and caught it in stride near the goal line.
Later, Seth Jacobs intercepted Mahomes' pass, and Garman kept the ball on a read play to put the Cowboys up by 17.
Follow Cliff Brunt on Twitter: http://www.twitter.com/CliffBruntAP.