INDIANAPOLIS — Tennessee quarterback Jake Locker is inactive for Sunday's game because of a right wrist injury.
He will be replaced by Charlie Whitehurst, who will make his fifth career start, but hasn't thrown a pass since 2011.
The Titans (1-2) listed Locker questionable all week after getting hurt in last week's loss at Cincinnati.
Indianapolis (1-2) deactivates center Khaled Holmes and guard Hugh Thornton, both starters. Linebackers Jerrell Freeman and Andy Studebaker, defensive tackle Arthur Jones, safety Colt Anderson, and receiver Da'Rick Rogers also are inactive.