Williams, with a back injury, and Easley (left leg) will both miss their third straight games.
Running back Fred Jackson is listed as questionable because of a sore right ankle. Jackson also missed practice Friday because of the flu.
Starting defensive tackle Kyle Williams is listed as questionable. He has practiced all week and has a chance to return after missing one game with a right knee injury.
The Bills and AFC East rival Patriots both have 3-2 records.