Kyle Singler scored 21 points, going 5 of 7 from 3-point range to keep the Pistons close. Greg Monroe had 16 points and 11 rebounds for Detroit, while Brandon Jennings scored 14 points and Josh Smith finished with 11.
Detroit's starting backcourt struggled, as Jennings and Kentavious Caldwell-Pope were a combined 7 of 27, with Caldwell-Pope missing 10 of his 11 shots.
Detroit still shot 42 percent, while Memphis made just 37 percent. Vince Carter missed nine of his 10 shots and Randolph was 7 of 22.