Manager Luis Enrique says "he will have some minutes for sure. It is important for him to be incorporated in the team."
Suarez hasn't played an official match since biting Italy's Giorgio Chiellini in June.
The Uruguay forward finishes his ban on Saturday, just before Barcelona visits Madrid looking to extend its lead of the Spanish league.
Undeterred by his latest act of gross misconduct, Barcelona spent 97 million euros (then $130 million) to sign him from Liverpool this summer.
Besides Suarez's highly anticipated debut, Lionel Messi will be seeking the one goal he needs to equal the league's all-time leading scoring mark of 251 goals.