Nestrasil, Xavier Ouellet and Riley Sheahan scored in regulation for Detroit and Petr Mrazek made 20 saves. The Red Wings finished the preseason 4-3-1.
Patrice Bergeron had three goals for Boston. He tied it at 3 on a power play midway through the third.
Tuukka Rask stopped 26 shots for Boston. The Bruins finished the preseason 3-2-2.