NORMAN, Oklahoma — Kansas appeared to have built momentum under interim coach Clint Bowen with its close loss to No. 5 TCU last week.
Samaje Perine stopped the Jayhawks in their tracks. The true freshman set a major college record by running for 427 yards in a driving rainstorm, scoring five touchdowns and leading the No. 23 Sooners over the Jayhawks 44-7 on Saturday.
A week after Wisconsin's Melvin Gordon set the mark by rushing for 408 yards against Nebraska, Perine ran past him. Perine broke the record on his 34th and final carry, a 42-yard run with 12:16 left in the fourth quarter.
The yardage and touchdown totals were the most by a Kansas opponent.
"What we didn't do was stop him in any way, shape or form," Bowen said. "They obviously had a good game plan. Their offensive line played very physically, came off the ball hard and got movement on us. He is a tough guy to bring down."
The Jayhawks (3-8, 1-7 Big 12) lost their 29th straight true road game and 32nd in a row straight outside of Lawrence. Defensive tackle Keon Stowers said the Jayhawks have to get back on track in time for their game at Kansas State next Saturday.
"If we keep thinking about it, that's going to carry over to next week," Stowers said. "We got blown out by Baylor, and came back the next week to beat Iowa State. We just have to use that same resilience and same fight that we have had this whole season. Just keep going."
The Jayhawks failed to produce any points on offense and gained just 103 yards. Kansas' lone touchdown came when Cassius Sendish returned Keith Ford's fumble 63 yards. The Sooners have won 10 straight in the series. The Jayhawks haven't beaten Oklahoma since 1997 and haven't won in Norman since 1996.
Perine carried the Sooners (8-3, 5-3) on an afternoon when they were without their top passing threats. Quarterback Trevor Knight sat out because of a neck injury, and top receiver Sterling Shepard, who had been dealing with a nagging groin injury, left after a punt return in the first quarter. Tight end Blake Bell, who was second on the team with four touchdown catches, was out due to a strained knee.
The injuries and the weather forced Oklahoma to depend almost entirely on its power running game. Perine's first carry resulted in his 15th touchdown rushing, tying Adrian Peterson for Oklahoma's freshman record.
On his first carry of the second half, Perine bolted for his longest run of the season, a 66-yarder that made it 31-0.
Later in the third quarter, the crowd started chanting "Pe-rine! Pe-rine!" and he delivered. He got loose for a 27-yard touchdown run on fourth-and-2 to push the lead to 41-7.
"He is 245 pounds and runs fast," Bowen said. "He changes direction, had great strength and power, and has great vision. I don't think there is anything bad about the kid.
"He is a special running back, one of the better ones in the conference going back to Ricky Williams and Adrian Peterson and those guys. He is going to have that kind of career in the Big 12."
Follow Cliff Brunt on Twitter: http://www.twitter.com/CliffBruntAP.