Anthony, who led Syracuse to its only national championship in 2003, also had seven rebounds in 27 minutes at the Carrier Dome. He was 5 for 12 from the field and 6 for 8 at the free-throw line.
Two more former Syracuse stars took the night off. Philadelphia was without Michael Carter-Williams, who had right shoulder surgery in May, and rookie Jerami Grant, who was sidelined by an ankle injury.
Tony Wroten and Nerlens Noel led the 76ers with 12 points apiece. Noel also had 11 rebounds and four steals.
New York had a 17-1 run in the first quarter and led 45-29 at halftime.
Philadelphia shot 38 percent from the field, including a 2-for-18 performance from 3-point range.