Jamierra Faulkner added 16 points for Chicago (13-8), which had six players score in double figures. The Sky shot 72 percent in the first half and 63 for the game en route to sweeping the four-game season series for the first time in team history.
With Secretary of Education Arne Duncan courtside in a pink Sky t-shirt, Chicago raced to 17-point lead with a season-high 57 points in the first half. The lead reached 28 points with an 8-0 run in the third quarter that included free throws after Shavonte Zellous picked up two technicals and was ejected.
Maggie Lucas scored 14 points for Indiana (11-9), which had won three straight and eight of 10.