Chris Paul had 11 points and eight assists. He committed one turnover in 24 minutes, after getting six in each of his previous two games. Paul finished last season with a league-best 4.57 assist-to-turnover ratio. Jodie Meeks had 20 points for Detroit.
J.J. Redick scored 14 points, and his streak of 29 games with a 3-pointer ended one game shy of teammate Matt Barnes' franchise record.
Jodie Meeks had 20 points and Andre Drummond had 18 points and 13 rebounds for the Pistons, who were coming off road wins against Phoenix and Sacramento after losing 13 straight.
The Clippers led 55-44 at halftime. Griffin set up a pair of alley-oop dunks by Jordan 68 seconds apart, capping a 16-4 run that turned a one-point deficit into a 47-36 lead with 4:41 left in the second quarter.
Los Angeles extended its lead to 73-53 on a four-point play by Barnes, who was fouled by Kyle Singler on a jumper with 4:57 left in the third quarter. The Pistons got no closer than 16 points after trailing by 27.
Griffin's final basket was a 3-pointer with 27.8 seconds left in the third. With the lead secure, Griffin sat out the fourth quarter.
Jordan Farmar's 3-pointer with 4.8 seconds left in the first quarter put the Clippers ahead 29-27. They had trailed by nine points and committed seven turnovers that were converted into 11 points. Redick made his first five shots.
Pistons coach Stan Van Gundy received a technical foul with 7:34 left in opening quarter after Brandon Jennings was called for a foul, and Drummond got one about 2 minutes later for complaining about a non-call.
Pistons: All five of their victories have come against teams that entered Monday night's games with losing records. Last season, 19 of their wins were against clubs that finished under .500, and 10 were against teams that ended up with winning records — including one each against division champions San Antonio, Indiana and Miami. ... The Pistons haven't shot 50 percent or better from the field in any of their first 25 games. Last season they did it 11 times. ... (IF) Drummond has 81 double-digit rebound games since the start of last season, the second-most in the league during that stretch behind Jordan's 94.
Clippers: Redick made a career-high eight 3-pointers against the Pistons on Jan. 27, 2013, when he was with Orlando. ... The Clippers have beaten Detroit eight straight times, their third-longest active winning streak against one club behind Utah (11) and Minnesota (10). ... Reserve G Chris Douglas-Roberts, who was born in Detroit and played high school ball there, had nine points in 24 minutes in his second game back after missing the previous 15 because of a strained right Achilles.
Pistons: Host Dallas on Wednesday.
Clippers: Host Indiana on Wednesday.