The win snaps a four-game losing skid for Hartford (12-11, 5-5 America East) and marks the second-straight season sweep of Binghamton, which saw a two-game winning streak end.
The Bearcats (4-21, 3-7) hadn't led since the first half but cut a 17-point Hartford lead down to 47-45 when Yosef Yacob scored the second of two 3-pointers.
Justin Graham and Taylor Dyson scored back-to-back 3s for Hartford, then Sikma and Wroe pushed the lead back to eight, 59-51 with two minutes left. Magnus Richard hit a 3-pointer for Binghamton with no time left.
Jack Hobbs led Hartford with 12 points and Graham added 11. Sikma added nine points and seven rebounds.