The loss was the 76ers' 10th straight to open their season and 20th overall dating back to last season.
Tony Parker scored 16 points and Tim Duncan added 15 for San Antonio, which has won four straight and is 3-0 at home.
Philadelphia rookie center Jahlil Okafor had 21 points and 12 rebounds for his second double-double. Nerlens Noel, returning after a two-game absence due to a sore wrist, was limited to six points and three rebounds.
San Antonio was without Kawhi Leonard and Manu Ginobili, but their absence wasn't felt against a young Philadelphia squad.
The Spurs went on a 10-0 run after Noel banked in the opening shot, with Aldridge and Duncan setting up their younger counterparts. Aldridge opened the run with a layup off a feed from Duncan after sealing off Noel. Duncan closed the burst with a 17-foot jumper ahead of a charging Okafor, who did not see the Spurs veteran drift from the paint.
Okafor scored seven points during a 14-2 run that pulled Philadelphia within 87-83 with three minutes remaining, but the Spurs forced three straight turnovers to seal the victory.
76ers: Noel, who has a team-high four double-doubles this season, was limited to 2-for-8 shooting. ... Philadelphia had six players out with injury, including C Joel Embiid. The 7-foot Embiid is expected to miss the season following a second surgery on his right foot, but he is listed as right foot injury. ... Philadelphia's last victory against San Antonio came at home on Feb. 11, 2011.
Spurs: San Antonio played France's National Anthem after a moment of silence before tipoff to honor the victims of the terrorist attacks in Paris. Parker and Boris Diaw are both from France. ... Second-year player Kyle Anderson made his first start of the season in place of Leonard. Anderson, who started eight games last season, had 10 points and seven rebounds in 30 minutes. ... San Antonio recalled Jonathon Simmons from its Development League affiliate prior to Saturday's game.
76ers: At Dallas on Monday.
Spurs: Host Portland on Monday.