ORCHARD PARK, New York — New coach Rex Ryan and the Buffalo Bills' attacking defense weren't sounding so brash and bold after Tom Brady got through with them.
Ryan was left taking the blame and muttering a profanity following a 40-32 loss on Sunday in what's become an all-too familiar result against Brady and the New England Patriots.
"It's on my shoulders," Ryan said. "I've been on the wrong end of it a few times when the kid gets hot, and Brady was hot."
Brady actually took his game to a new level in improving his record to 24-3 against the Bills no matter who's coaching them.
He threw three touchdowns and combined for 466 yards passing — the second-most of his career and most by any player against Buffalo (1-1). Bill Belichick's Patriots (2-0) extended their own run of dominance by improving to 27-3 in the past 30 meetings against their AFC East rivals.
"Belichick outcoached me. No question about it," Ryan added. "The plan has to be better on defense. You can't give up 500 yards and beat anyone."
That's a far cry from the "bully," Ryan vowed to build when taking over for Doug Marrone this offseason.
The Patriots scored on three consecutive possessions over a span of 5:48 between the first and second quarters to build a 21-7 lead. And they eventually led 37-13 before the Bills' fourth-quarter rally fell short.
After rookie Karlos Williams scored on a 2-yard run to cap an 80-yard opening drive, Buffalo combined for just 47 yards over its nine possessions.
Tyrod Taylor went 23 of 30 for 242 yards, with three touchdowns and three interceptions. Taylor also scored on a 7-yard run, but he was sacked eight times.
Taylor's third interception ended Buffalo's comeback bid with 1:07 left, when his pass glanced off the fingers of receiver Sammy Watkins and was picked off by cornerback Logan Ryan.
"I need to take care of the ball," Taylor said. "You can't end the game with three turnovers, that's the real deal. Two of them came in two-minute drills."
The Bills had a scare when starting safety Aaron Williams was loaded into an ambulance on the field and taken to the hospital after sustaining a neck injury late in the third quarter. The team announced Williams was released from the hospital after undergoing a series of tests.
Buffalo unraveled on both sides of the ball, looking nothing like the team coming off a 27-14 season-opening win over Indianapolis.
"We need to be smarter," defensive end Mario Williams said. "We dug ourselves a hole and it's up to us to get out of it."
Discipline was also a big problem. The Bills were penalized 14 times for 140 yards.
One of those penalties was against Ryan, who shouted down an official after a second-half defensive holding call against rookie cornerback Ronald Darby.
"That was mine," Ryan acknowledged. "The guy's got rabbit ears."
Brady took the air out of what began as a raucous environment at Ralph Wilson Stadium. Bills fans were buzzing all week in a bid to set a record for loudest outdoor stadium. They even raised enough money to have a Guinness World Record official on hand to measure the decibel level. The results were not revealed and fans began heading for the exits in the final minute of the third quarter, after Gostkowski hit a 50-yard field goal to up New England's lead to 37-13.