Coach Rex Ryan provided an update on Monday, a day after Watkins left in the second quarter of the Bills' 41-14 win at Miami.
Ryan said "it's a possibility" Watkins won't be available this week. Bills players had Monday off.
Watkins, the second-year receiver, has seven receptions for 99 yards and a touchdown through the first three games.
The Bills (2-1) host the Giants (1-2) on Sunday.